产品参数
Ex (nm) - Em (nm) -
分子量 N/A 溶剂 DMSO
存储条件 在零下15度以下保存, 避免光照
产品概述
产品基本信息
产品名称：2',3'-cGAMP-DBCO 偶联物
储存条件：-15℃避光防潮
保质期：12个月
产品物理化学光谱特性
分子量：1539.59
外观：固体
溶剂：DMSO
激发波长(nm)：NA
发射波长(nm)：NA
DBCO（二苯并环辛炔）点击化学是一种生物偶联技术，用于将分子共价连接到生物靶标，例如蛋白质、肽和核酸。它涉及在无铜催化剂存在下 DBCO 官能化分子与互补叠氮官能化分子之间的反应，形成稳定的三唑键。 2',3'-cGAMP-DBCO 偶联物是开发用于研究 2',3'-cGAMP 的生物活性和功能的 2',3'-cGAMP 探针的构件。 2',3'-cGAMP 近年来因其作为癌症和病毒感染等病症医治靶点的潜力而受到广泛关注。它已被证明可以激活免yi系统并增强免yi检查点抑制剂的功效，这是一种癌症免yi疗法。 2',3'-cGAMP（环状 GMP-AMP）是一种环状二核苷酸二信使分子，在先天免yi系统中起着至关重要的作用。它由酶 cGAS（环状 GMP-AMP 合酶）合成，以响应从受损或感染细胞中释放的胞质 DNA。一旦合成，2',3'-cGAMP 就会与衔接蛋白 STING（干扰素基因刺激物）结合并触发下游信号通路，从而产生 I 型干扰素和其他细胞因子，从而导致针对入侵病原体的免yi反应。
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