RGD-荧光近红外750

近红外荧光光学成像（又称活体成像）是一种在分子水平上研究小动物病症的技术。水和生物组织在近红外（650-900纳米）中具有小的吸光度和自荧光，从而允许有效的光子进出组织，且组织内散射较低。通过这个近红外光线，生理上丰富的分子如血红蛋白、氧血红蛋白和脱氧血红蛋白对光的吸收也降到低。具有生物相容性荧光剂的活体成像系统正在开发和优化，以用于近红外光谱区域-确保大的光穿透和高的灵敏度。细胞粘附分子整合素参与多种肿瘤的血管生成和转移。整合素在活化的内皮细胞和快速生长的实体瘤细胞中明显上调，而在静止的血管和大多数正常组织中表达低。 iFluor 750标记的单体精氨酸-甘氨酸-天冬氨酸（RGD）肽c（RGDyK）专门针对细胞培养和活体内的整联蛋白。 iFluor 750-c（RGDyK）的体内功效取决于许多因素，包括受体亲和力，特异性，分子大小，总分子电荷，亲水性和代谢稳定性。

参考文献

99mTc-Glu-c(RGDyK)-Bombesin SPECT Can Reduce Unnecessary Biopsy of Masses That Are BI-RADS Category 4 on Ultrasonography
Authors: Ji T, Gao S, Liu Z, Xing H, Zhao G, Ma Q.
Journal: J Nucl Med (2016): 1196

In Vivo Biodistribution and Anti-Tumor Efficacy Evaluation of Doxorubicin and Paclitaxel-Loaded Pluronic Micelles Decorated with c(RGDyK) Peptide
Authors: Chen Y, Zhang W, Huang Y, Gao F, Fang X.
Journal: PLoS One (2016): e0149952

Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization
Authors: P and ya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ.
Journal: Theranostics (2016): 698

c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma
Authors: Huang Y, Liu W, Gao F, Fang X, Chen Y.
Journal: Int J Nanomedicine (2016): 1629